Itsaso Arana has built an extensive career as an actress and creator. She has starred in Jonás Trueba’s feature films You Have To Come And See It (2022), winner of the Special Jury Prize at the Karlovy Vary International Film Festival; The August Virgin (2019), which received a Special Jury Mention and the FIPRESCI Award at Karlovy Vary and was named one of the Top 10 Films of 2020 by Cahiers du Cinéma; and The Reconquest (2016), part of the Official Selection at the San Sebastian Film Festival.

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Itsaso Arana is known for her roles in prominent films and series, including Las Altas Presiones (2014) by Ángel Santos, Seventeen (2019) by Daniel Sánchez Arévalo, and The Volunteer (2022) by Nely Reguera. She has also appeared in acclaimed series such as Reyes de la noche and The Girls at the Back.

In 2004, Itsaso co-founded La Tristura, a scenic arts group where she creates, directs, and performs in productions showcased in theaters and prestigious festivals across Spain, France, Germany, Finland, Poland, Brazil, and beyond.

Her directorial debut, The Girls Are Alright (Las chicas están bien, 2023), which she wrote and co-stars in, blends cinema and theater. The film follows four actresses and a writer rehearsing for a stage play in an old mill.